Publication

Over 40 journal publications, including 10 in Nature Biomedical Engineering, Nature Photonics, Nature Methods, Nature Protocols, Science Robotics, Nature Communications, and Science Advances. Google Scholar: Total citation >2400, h-index, 23

(*co-first author)

Selected Publications


2021

  • L. Li, Y. Li, Y. Zhang, L. V. Wang. “Snapshot photoacoustic topography through an ergodic relay of optical absorption in vivo,' Nature Protocols 16, 2381–2394

    • Featured by Nature Protocols in April, 2021

2020

  • Y. Li*, L. Li*, L. Zhu*, K. Maslov, J. Shi, P. Hu, E. Bo, J. Yao, J. Liang, L. Wang, L. V. Wang. “Snapshot photoacoustic topography through an ergodic relay for high-throughput imaging of optical absorption,' Nature Photonics 14, 164–170

2019

  • Shi, J., T. T. Wong, Y, He, L. Li, R. Zhang, C. Yung, J. Hwang, K. Maslov, L. V. Wang. “High-resolution, high-contrast mid-infrared imaging of fresh biological samples with ultraviolet-localized photoacoustic microscopy,' Nature Photonics 13(9), 609–615

2018

  • L. Li, A. A. Shemetov, M. Baloban, P. Hu, L. Zhu, D. M. Shcherbakova, R. Zhang, J. Shi, J. Yao, L. V Wang, V. V. Verkhusha. “Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo,' Nature Communications 9 (1), 2734, 1–14

    • Indexed by Nature Index

2017

2016

  • J. Yao*, A. A. Kaberniuk*, L. Li*, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, L. V. Wang. “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,' Nature Methods 13, 67–73

2015

Peer Reviewed Journal Articles


2021

  • L. Li, H. Hsu, V. V. Verkhusha, L. V. Wang, D. M. Shcherbakova, “Multiscale photoacoustic tomography of a genetically encoded near-infrared FRET biosensor,” Advanced Science e2102474.

  • D. Lee, C. Qian, H. Wang, L. Li, K. Miao, J. Du, D. M. Shcherbakova, V. V. Verkhusha, L. V. Wang, L. Wei, "Toward photoswitchable electronic pre-resonance stimulated Raman probes", The Journal of Chemical Physics 154, 135102

  • M. Ochocinska, S. Spitalnik, A. Abuhamad, E. Bennett-Guerrero, W. Carlo, M. Cherukuri, A. Doctor, W. Dzik, C. Evans, E. Forzani, P. Kuppusamy, N. Moan, L. Li, N. Luban, N. Mohandas, R. Patel, J. Roback, H. Swartz, S. Textor, Sergei. Vinogradov, L. V. Wang, N. Wisniewski, S. Glynn. “NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion,” Transfusion Medicine Reviews 35(1):46-55. doi: 10.1016/j.tmrv.2020.12.003.

  • L. Li, Y. Li, Y. Zhang, L. V. Wang. “Snapshot photoacoustic topography through an ergodic relay of optical absorption in vivo,” Nature Protocols 16, 2381–2394

  • L. Li, D. Patil, G. Petruncio, K. Harnden, J. Somasekharan, M. Paige, L. V. Wang, C. S. Morales. “Integration of multitargeted polymer-based contrast agents with photoacoustic computed tomography: An imaging technique to visualize breast cancer intratumor heterogeneity,” ACS Nano 15(2): 2413–2427

2020

  • P. Hu, L. Li, L. Lin, L. V. Wang. “Spatiotemporal antialiasing in photoacoustic computed tomography,” IEEE Transactions on Medical Imaging 39(11): 3535-3547

  • Y. Li, L. Li, L. Zhu, J. Shi, K. Maslov, L. V. Wang. “Photoacoustic topography through an ergodic relay for functional imaging and biometric application in vivo,” Journal of Biomedical Optics 25(7): 070501, 1–8

  • Y. Li*, L. Li*, L. Zhu*, K. Maslov, J. Shi, P. Hu, E. Bo, J. Yao, J. Liang, L. Wang, L. V. Wang. “Snapshot photoacoustic topography through an ergodic relay for high-throughput imaging of optical absorption,” Nature Photonics 14, 164–170

  • J. Yang, L. Li, J. Li, Z. Cheng, Y. Liu, L. V. Wang. “Fighting against fast speckle decorrelation for light focusing inside live tissue by photon frequency shifting,” ACS Photonics 7(3): 837–844

2019

  • J. Yang*, L. Li*, A. A. Shemetov, S. Lee, Y. Zhao, Y. Liu, Y. Shen, J. Li, Y. Oka, V. V. Verkhusha, L. V. Wang. “Focusing light inside live tissue using reversibly switchable bacterial phytochrome as a genetically encoded photochromic guide star,' Science Advances 5 (12), eaay1211

  • Z. Wu*, L. Li*, Y. Yang, P. Hu, Y. Li, S. Yang, L. V. Wang and W. Gao. "A microrobotic system guided by photoacoustic computed tomography for targeted navigation in intestines in vivo," Science Robotics 4 (32): eaax0613

  • Shi, J., T. T. Wong, Y, He, L. Li, R. Zhang, C. Yung, J. Hwang, K. Maslov, L. V. Wang. “High-resolution, high-contrast mid-infrared imaging of fresh biological samples with ultraviolet-localized photoacoustic microscopy,' Nature Photonics 13(9), 609-615

  • P. Zhang*, L. Li*, L. Lin, J. Shi, L. V. Wang. “In vivo superresolution photoacoustic computed tomography by localization of single dyed droplets,” Light: Science & Applications 8(36), 1–9

2018

  • L. Li, A. A. Shemetov, M. Baloban, P. Hu, L. Zhu, D. M. Shcherbakova, R. Zhang, J. Shi, J. Yao, L. V Wang, V. V. Verkhusha. “Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo,' Nature Communications 9 (1), 2734 (Indexed by Nature Index)

  • HC. Hsu, L. Li, J. Yao, T.W. Wong, J. Shi, R. Chen, Q. Zhou, L. V. Wang. “Dual-axis illumination for virtually augmenting the detection view of optical-resolution photoacoustic microscopy,' Journal of Biomedical Optics 23 (7), 076001

  • L. Lin, P. Hu, J. Shi, C. Appleton, K. Maslov, L. Li, R. Zhang, L. V. Wang. “Single-Breath-Hold Photoacoustic Computed Tomography of the Breast,' Nature Communications 9 (1), 2352

  • T. P. Matthews, J. Poudel, L. Li, L. V. Wang, M. A. Anastasio. “Parameterized Joint Reconstruction of the Initial Pressure and Sound Speed Distributions for Photoacoustic Computed Tomography,' SIAM journal on imaging sciences 11 (2), 1560-1588

  • Y. Qu*, L. Li*, Y. Shen, X. Wei, T. W. Wong, P. Hu, J. Yao, K. Maslov, and L. V. Wang. “Dichroism-sensitive photoacoustic computed tomography,' Optica 5, 495-501

  • T. Imai, J. Shi, T. TW Wong, L. Li, L. V. Wang. “High-throughput ultraviolet photoacoustic microscopy with multifocal excitation,' Journal of Biomedical Optics 23(3), 036007

  • P. Zhang*, L. Li*, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, L. V. Wang. “High–resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,' Journal of Biophotonics 11(2), e201700196-n/a

  • W. Liu, Y. Zhou, M. Wang, L. Li, E. Vienneau, R. Chen, J. Luo, C. Xu, Q. Zhou, L. V. Wang, J. Yao. “Correcting the limited view in optical-resolution photoacoustic microscopy,' Journal of Biophotonics 11(2), e201700024-n/a

2017

  • L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, L. V. Wang. “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,' Nature Biomedical Engineering 1, 0071 (Highlighted as cover articles in Nature Biomedical Engineering in issue 5, 2017, selected as a top 10 article for the first anniversary, top 10 most cited research article in Nature Biomedical Engineering)

  • L. Li, L. Zhu, Y. Shen, L. V. Wang. “Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography,' Journal of Biomedical Optics 22 (7), 076017

  • J. Poudel, T. P. Matthews, L. Li, M. A. Anastasio, L. V. Wang, “Mitigation of artifacts due to isolated acoustic heterogeneities in photoacoustic computed tomography using a variable data truncation-based reconstruction method,' Journal of Biomedical Optics 22 (4), 041018-041018

  • T. Wong, Y. Zhou, A. Garcia-Uribe, L. Li, K. Maslov, L. Lin, L. V. Wang. “Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo,” Journal of Biomedical Optics 22(4), 041003, 1–6

  • L. Lin, P. Zhang, S. Xu, J. Shi, L. Li, J. Yao, L. Wang, J. Zou, L. V. Wang. “Handheld optical-resolution photoacoustic microscopy,' Journal of Biomedical Optics 22(4), 041002

  • C. Yeh*, L. Li*, L. Zhu, J. Xia, C. Li, W. Chen, A. Garcia-Uribe, K. Maslov, L. V. Wang. “Dry coupling for whole-body small-animal photoacoustic computed tomography,' Journal of Biomedical Optics 22 (4), 041003-041003

  • B. Rao, R. Zhang, L. Li, J. Shao, L. V. Wang. “Photoacoustic imaging of voltage responses beyond the optical diffusion limit,' Scientific Reports 7, 2560

2016

  • L. Li, J. Xia, A. Garcia-Uribe, Q. Sheng, M. Anastasio, and L. V. Wang. “Label-free photoacoustic tomography of whole mouse brain structures ex vivo,' Neurophotonics 3(3), 035001

  • J. Yao*, A. A. Kaberniuk*, L. Li*, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang. “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,' Nature Methods 13, 67–73

  • L. Lin, J. Yao, L. Li, L. V. Wang. “In vivo photoacoustic tomography of myoglobin oxygen saturation,' Journal of Biomedical Optics 21(6), 061002.

  • Y. He, L. Wang, J. Shi, J. Yao, L. Li, R. Zhang, C. Huang, J. Zou, L. V. Wang, “In vivo label-free photoacoustic flow cytography and on-the-spot laser killing of single circulating melanoma cells,' Scientific Reports 6, 39616

2015

  • J. Yao, L. Wang, J. M. Yang, K. Maslov, T. Wong, L. Li, C. H. Huang, J. Zou, L. V. Wang. “High-speed Label-free Functional Photoacoustic Microscopy of Mouse Brain in Action,' Nature Methods 12, 407–410

  • G. Li, L. Li, L. Zhu, J. Xia, L. V. Wang. “Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array,' Journal of Biomedical Optics 20 (6), 066010

  • L. Lin, J. Xia, T. Wong, L. Li, L. V. Wang, “In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography,' Journal of Biomedical Optics 20 (1), 016019

2014

  • L. Zhu*, L. Li*, L. Gao, L. V. Wang. “Multi-view optical resolution photoacoustic microscopy,' Optica 1(4), 217-222

  • L. Li, C. Yeh, S. Hu, L. Wang, B. T. Soetikno, R. Chen, Q. Zhou, K. K. Shung, K. Maslov, L. V. Wang (2014). “Fully motorized optical-resolution photoacoustic microscopy,' Optics Letters 39 (7), 2117-2120 (Highlighted as cover article in Optics Letters in issue 7, 2014; selected for re-exposure by Virtual Journal for Biomedical Optics)

  • Y. S. Zhang, J. Yao, C. Zhang, L. Li, L. V. Wang, Y. Xia. “Optical-resolution photoacoustic microscopy for volumetric and spectral analysis of histological and immunochemical samples,' Angewandte Chemie International Edition. doi: 10.1002/anie.201403812

2013 and before

  • J. Cui, L. Li, J. Tan (2013). “Sensing technology and method based on double fiber coupling of return energy for micro-hole measurement,' Sensors and Actuators A: Physical 190, 13-18

  • J. Cui, L. Li, J. Tan (2012). “Opto-tactile probe for inner dimension measurement with high aspect ratio,' Measurement Science and Technology 23 (8), 085105

  • J. Cui, L. Li, J. Tan (2011). “Optical fiber probe based on spherical coupling of light energy for inner-dimension measurement of microstructures with high aspect ratio,' Optics Letters 36 (23), 4689-4691

Book Chapters and Review Articles


  • L. Li, J. Yao, L. V. Wang (2019). “Photoacoustic tomography of neural system,' in Neural Engineering (In press)

  • L. Li, L. Lin, L. V. Wang (2018). “Multiscale photoacoustic tomography,' in Optics and Photonics News 29(4) 32-39 (Invited review article)

  • M. Zhou*, L. Li*, J. Yao, R. R. Bouchard, L. V. Wang, C. Li (2017). “Nanoparticles for Photoacoustic Imaging of Vasculature,' in Design and Applications of Nanoparticles in Biomedical Imaging, 337–356

  • L. Li, J. Yao, L. V. Wang (2016). “Photoacoustic Tomography Enhanced by Nanoparticles,' in Wiley Encyclopedia of Electrical and Electronics Engineering, J. G. Webster (Ed.). doi:10.1002/047134608X.W8335

Conference Proceedings


  • L. Li, A. A. Shemetov, P. Hu, D. M. Shcherbakova, J. Shi, J. Yao, V. V. Verkhusha, L. V. Wang (2019). “In vivo photoacoustic multi-contrast imaging and detection of protein interactions using a small near-infrared photochromic protein,' SPIE BiOS, 1087818-6

  • L. Li, P. Zhang, L. V. Wang (2018). “Linear-array based full-view high-resolution photoacoustic computed tomography of whole mouse brain functions in vivo,' SPIE BiOS, 104941H-6

  • L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, L. V. Wang, (2017). “Imaging small animal whole-body dynamics by single-impulse panoramic photoacoustic computed tomography,' SPIE BiOS, 100640M-6

  • J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, 6 / 7 (2016). “Reversibly switchable photoacoustic tomography using a genetically encoded near-infrared phytochrome,' SPIE BiOS, 97082U-8

  • T. P. Matthews, L. Li, L. V. Wanga, M. Anastasia (2016). “Compensation for air voids in photoacoustic computed tomography image reconstruction,' SPIE BiOS, 970841-6

  • G. Li, J. Xia, L. Li, L. Wang, L. V. Wang (2015), “Isotropic-resolution linear-array-based photoacoustic computed tomography through inverse Radon transform,' SPIE BiOS, 93230I-7

  • C. Yeh, S. Hu, J. Liang, L. Li, B. Soetikno, Z. Lu, R. Sohn, K. Maslov, J. M. Arbeit, L. V. Wang (2015). “Opticalresolution photoacoustic microscopy of the metabolic rate of oxygen in a mouse renal tumor model,' SPIE BiOS, 93233H-8

  • L. Li, C. Yeh, S. Hu, L. Wang, B. T. Soetikno, K. Maslov, R. Chen, Q. Zhou, K. K. Shung, L. V. Wang (2014). “Fully motorized optical-resolution photoacoustic microscopy,' BIOMED, BS3A.69

  • L. Zhu, L. Gao, L. Li, L Wang, T Ma, Q Zhou, K. K. Shung, L. V. Wang (2014). “Cross-optical-beam nonlinear photoacoustic microscopy,' SPIE BiOS, 89433H-5

  • L. Li, C. Yeh, S. Hu, L. Wang, B. T. Soetikno, R. Chen, Q. Zhou, K. K. Shung, K. Maslov, L. V. Wang (2014). “Combined optical and mechanical scanning in optical-resolution photoacoustic microscopy,' SPIE BiOS, 89435X-6

  • J. Cui, L. Li, J. Tan (2010). “Development of ultra-precision micro-cavity measurement technique in HIT-UOI,' Proc. SPIE 7544, 75441A; doi:10.1117/12.885701